Bruce L Miller Selected Research

Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)

11/2022	Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.
1/2021	Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
1/2021	Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease.
1/2021	Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
12/2020	Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
1/2020	Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.
10/2019	Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.
1/2019	Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
1/2019	Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
1/2019	Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

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Bruce L Miller Research Topics

Disease

117	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 07/2002
71	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 11/2003
54	Dementia (Dementias) 01/2022 - 02/2004
52	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2022 - 03/2004
40	Cognitive Dysfunction 01/2022 - 03/2005
34	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 02/2009
25	Atrophy 01/2022 - 05/2006
21	Tauopathies 01/2022 - 06/2002
14	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2021 - 03/2004
14	Corticobasal Degeneration 01/2020 - 06/2008
13	Primary Progressive Aphasia 01/2021 - 10/2008
12	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 10/2006
9	Disease Progression 01/2022 - 02/2008
8	Inflammation (Inflammations) 02/2022 - 11/2011
8	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2019 - 06/2006
7	Parkinson Disease (Parkinson's Disease) 01/2021 - 10/2009
6	Sporadic Creutzfeldt-Jakob Disease 01/2021 - 06/2003
6	Pick Disease of the Brain (Pick's Disease) 01/2018 - 06/2002
6	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 10/2015 - 02/2004
5	Sarcoma (Soft Tissue Sarcoma) 04/2014 - 07/2010
3	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 01/2019
3	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2022 - 03/2005
3	Amyloid Plaque 05/2021 - 04/2015
3	TDP-43 Proteinopathies 12/2020 - 12/2013
3	Amyloidosis 01/2017 - 10/2008
3	Neuroinflammatory Diseases 01/2017 - 09/2011
3	Mental Disorders (Mental Disorder) 05/2016 - 01/2015
3	Multiple System Atrophy 12/2013 - 03/2004
2	Chronic Traumatic Encephalopathy 01/2022 - 01/2020
2	Memory Disorders (Memory Loss) 01/2022 - 01/2018
2	Pathologic Processes 12/2021 - 02/2019
2	Prodromal Symptoms 01/2021 - 02/2015
2	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 12/2019 - 12/2017
2	Type 2 Diabetes Mellitus (MODY) 01/2019 - 02/2015
2	Insulin Resistance 01/2018 - 02/2015
2	Proteostasis Deficiencies 01/2017 - 04/2014
2	Seizures (Absence Seizure) 01/2017 - 09/2013
2	Autoimmune Diseases (Autoimmune Disease) 12/2016 - 09/2013
2	Hyperphagia (Overeating) 06/2014 - 02/2014

Drug/Important Bio-Agent (IBA)

56	Biomarkers (Surrogate Marker)IBA 06/2022 - 06/2006
52	Amyloid (Amyloid Fibrils)IBA 06/2022 - 10/2008
41	Proteins (Proteins, Gene)FDA Link 05/2021 - 03/2007
32	ProgranulinsIBA 01/2021 - 03/2007
25	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2022 - 06/2008
21	Apolipoproteins E (ApoE)IBA 01/2022 - 05/2006
12	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2021 - 02/2017
12	Biological ProductsIBA 01/2021 - 06/2005
11	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 06/2022 - 10/2008
11	ApolipoproteinsIBA 01/2022 - 05/2006
10	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 05/2010
10	tau Proteins (tau Protein)IBA 01/2021 - 06/2002
7	UbiquitinIBA 12/2017 - 06/2005
7	Pharmaceutical PreparationsIBA 11/2016 - 05/2011
6	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 10/2008
5	Amyloid beta-PeptidesIBA 01/2022 - 02/2010
5	Apolipoprotein E4IBA 01/2021 - 02/2009
5	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 06/2008
5	PrionsIBA 01/2017 - 07/2006
4	Complement System Proteins (Complement)IBA 02/2022 - 07/2010
4	Butylated Hydroxyanisole (BHA)IBA 01/2021 - 01/2018
4	AntibodiesIBA 10/2019 - 06/2002
4	RNA (Ribonucleic Acid)IBA 01/2019 - 08/2011
4	Prion ProteinsIBA 10/2015 - 02/2004
3	TESIBA 01/2022 - 01/2019
3	Memantine (Namenda)FDA Link 01/2022 - 07/2009
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2022 - 04/2010
3	Retinaldehyde (Retinal)IBA 01/2022 - 09/2014
3	LipidsIBA 01/2021 - 01/2019
3	FluorineIBA 01/2021 - 01/2020
3	Indicators and Reagents (Reagents)IBA 01/2020 - 12/2016
3	Protein AggregatesIBA 01/2020 - 04/2014
3	Insulin (Novolin)FDA Link 01/2018 - 02/2014
3	RNA-Binding Protein FUSIBA 05/2013 - 07/2010
3	alpha-SynucleinIBA 10/2009 - 03/2004
2	Glial Fibrillary Acidic ProteinIBA 01/2022 - 01/2020
2	Peptides (Polypeptides)IBA 12/2021 - 11/2016
2	Levetiracetam (Keppra)FDA LinkGeneric 11/2021 - 09/2013
2	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 03/2005
2	Threonine (L-Threonine)FDA Link 01/2021 - 02/2015
2	GranulinsIBA 01/2021 - 06/2015
2	Protein Isoforms (Isoforms)IBA 12/2020 - 06/2002
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2020 - 09/2014
2	EnzymesIBA 12/2019 - 09/2012
2	Neurotransmitter Agents (Neurotransmitter)IBA 10/2019 - 05/2010
2	HDL LipoproteinsIBA 01/2019 - 07/2006
2	CholesterolIBA 01/2019 - 01/2019
2	LigandsIBA 01/2019 - 11/2018
2	Biological FactorsIBA 01/2019 - 01/2006
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018 - 09/2012
2	AD 20 (AD-20)IBA 01/2018 - 02/2015
2	ChemokinesIBA 03/2017 - 01/2016
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2017 - 12/2016
2	AD 5IBA 01/2015 - 01/2014
2	Ataxin-2IBA 10/2014 - 08/2011
2	SynucleinsIBA 12/2013 - 03/2004
2	Inositol (Myoinositol)IBA 01/2009 - 04/2006
2	14-3-3 Proteins (14-3-3 Protein)IBA 01/2007 - 06/2003
2	Presenilin-1IBA 02/2004 - 07/2002

Therapy/Procedure

22	Therapeutics 01/2022 - 11/2007
2	Long-Term Care 01/2021 - 11/2003